Last Updated: 04/29/2020

Pharmacogenomics (PGX)

Pharmacogenomics (PGX) is the study of how an individual’s unique DNA affects their response to certain medications.

PG testing (PGX) can provide information about medications and dosages that are the safest and most effective for each person.

What is Pharmacogenomics (PG)
How do genes affect our responses to medications?

How genes affect our response to medications

Certain gene mutations influence the processing of some medications ̶ how the body absorbs, uses, breaks down, or removes the drug.

If medications are not properly processed by our body because of a gene mutation, the medication may not be effective or could cause serious side effects.

The benefits and limitations of PGX

If you are taking a medication influenced by one or more of the genes in our PGX panel, it can provide information specific to you.

This testing can indicate which medications may be most effective, what dosing is right, and whether or not you are at risk for side effects.

PGX is limited, meaning it can only tell you about certain medications ̶ not all of them.

The benefits and limitations of PGX
How medications are usually prescribed

How medications are usually prescribed

Typically, health care providers rely on a “one size fits all” approach to prescribing medications.

The average dose, expected to obtain the desired effect, is prescribed without regard to an individual’s unique factors.

Typically, this method works only about half of the time, since average dosing does not take into account how a person’s own body may respond to a medication.

“One Size Fits All” model of prescribing medication

GETTING SICK HEALTHCARE PROVIDER VISIT MEDICATION PRESCRIBED GETTING WORSE FOLLOW-UP DOCTOR VISIT OR TRIP TO THE ER MEDICATION AND/OR DOSAGE ADJUSTED ON THE RIGHT TRACK

The Right medication at the Right dose at the Right time
means feeling better sooner*

Precision Medicine with Pharmacogenomic Testing

GETTING SICK HEALTHCARE PROVIDER VISIT PGX AT SCION GENOMICS MEDICATION AND DOSAGE PRESCRIBED ON THE RIGHT TRACK

* Based on medication usage and dosing impacted by PGX testing

Indications for Testing

PGX testing at Scion Genomics is recommended if you:

  • Are taking or planning to take a medication that is on our Therapeutic panels (see list).
  • Are taking multiple prescription medications.
  • Have experienced prescription medication treatment failure.
  • Have had a severe adverse drug reaction.
  • Are taking or planning to take a medications that the FDA requires/recommends PGX testing (see lists).

Talk to your health care provider about having testing.

Indications for Testing Testing must be ordered by your
doctor or health care provider

Therapeutic Panels

Enhancing Medication Safety

  •  Enhance efficacy
  •  Decrease adverse drug reactions
  •  Increase compliance
  •  Improve patient care

Psychiatric Drug Classes

  • Anti-ADHD Agents
  • Anticonvulsants
  • Antidementia Agents
  • Antidepressants
  • Antipsychotics
  • Anxiolytics
  • Cholinesterase Inhibitors
  • Hypnotics
  • Selective Serotonin Reuptake Inhibitors (SSRIs)
Click here for drug/Gene panel
Enhancing Medication Safety

Cardiac Drug Classes

  • Antiarrhythmics
  • Anticoagulants
  • Anticonvulsants
  • Antiplatelet Agents
  • Beta Blockers
  • Immunosuppressants
  • Statins
Click here for drug/Gene panel

PGX Gene Panels

Full Panel Psychiatric Panel Cardiac Panel Thrombosis Panel
  • APOE*2
  • CYP2C19
  • CYP2C9
  • CYP2D6
  • CYP3A4
  • CYP3A5
  • Prothrombin (F2)
  • Factor V Leiden (F5)
  • MTHFR
  • SLCO1B1
  • VKORC1
  • CYP2C19
  • CYP2C9
  • CYP2D6
  • CYP3A4
  • APOE*2
  • CYP2C19
  • CYP2C9
  • CYP2D6
  • CYP3A4
  • CYP3A5
  • SLCO1B1
  • VKORC1
  • Prothrombin (F2)
  • Factor V Leiden (F5)
  • MTHFR

Ordering Made Easy

Instructions for Healthcare Providers*

HEATH CARE PROVIDER CREATES ACCOUNT IN SCION PORTAL COMPLETE REQUISITION FORM PROVIDER CHOSES SAMPLING KIT SENT TO PATIENT’S HOME OR TO YOU - THE PROVIDER PATIENT OBTAINS SAMPLE FROM HOME OR PROVIDER OBTAINS SAMPLE AT AN OFFICE VISIT SAMPLE AND SIGNED CONSENT SHIPPED TO SCION
GENOMICS LABORATORY PROVIDER PORTAL RESULTS 14-21 DAYSY

* Testing must be ordered by your doctor or health care provider

PGX Results

We provide you with a comprehensive report and an online tool that is as dynamic as the people you treat.

Our GeneDoseTM Genetic Response Report

This report details each of the genetic variations identified and the potential clinical impact to the patient.

GeneDoseTM Report User Guide

GeneDose LiveTM

This dynamic risk management tool is available to health care providers after PGX genetic testing is completed on your patient.

GeneDose Live

You can add or remove information about your patient’s medical conditions, lifestyle and medication regime as well as view, real-time, the potential impact on the patient and what alternative medications to consider.

The tool’s link and log-in information are found on the first page of your patient’s PGX report. It’s simple to use, and the information provided makes it easy to alter as the patient’s situation changes.

GeneDose Live